And out of the three proteins, endocannabinoid release requires either gamma and beta together or alpha-synuclein by itself.

Effects might cancel each other out, which might explain why it takes such a large dose of CBD to protect the endocannabinoid system.

Cannabinoid receptors could not explain why cows given anandamide preferred sweeter water.

A recent study further mapped out how Fenofibrate crosstalks with endocannabinoids by chronically agonizing the PPAR receptor.

Discoveries tied together over two centuries now map an extensive endocannabinoid system found in nearly every animal.